Molecular Pharmacology Laboratory

Lab Description

The focus of the Molecular Pharmacology Laboratory is to understand the role of G protein-coupled receptors in human diseases. Our current focus is to examine the role of the Neurokinin-1/substance P receptor and its interactions with receptor tyrosine kinases in glioblastoma multiforme (GBM). The goal of these translational studies is to develop an effective therapy to halt the growth of GBM. An ongoing side project, which is being conducted in collaboration with several clinicians, is to understand the molecular basis of postoperative delirium.

For addition information on Dr. Kwatra’s lab, please visit

  1. Brown KB, Chagoya G., Kwatra SG, Yen T, Keir ST, Hoadley KA, Charles M. Perou, Ahmed Rasheed, Francis Ali-Osman, John H. Sampson, Darell D. Bigner, Madan M. Kwatra (2014). Patient-derived xenografts maintain the proteomic profile of human glioblastoma: Implications for personalized drug development. Journal of Neurochemistry.
  2. Brown et al. (2013) Subtype-specific expression of the truncated neurokinin-1 receptor in glioblastoma multiforme. Neuro-oncology 15: abstract # CB-009.
  3. Brown et al.(2012) Neurokinin-1 Receptor: A potential target to inhibit pediatric glioblastoma. Neuro-oncology 14: abstract # CB-51.
  4. Kwatra M, et al. (2011) Truncated Neurokinin-1 Receptor: Expression in Primary Glioblastoma and Realtionship with Patient Survival. Neuro-oncology 13: abstract # OM-28.
  5. Akazawa T, Kwatra SG, Goldsmith LE, Richardson MD, Cox EA, et al. (2009) A constitutively active form of neurokinin 1 receptor and neurokinin 1 receptor-mediated apoptosis in glioblastomas. J Neurochem 109: 1079-1086.

Madan M. Kwatra, PhD

Madan Kwatra, PhD

Laboratory Director
Associate Professor in Anesthesiology
Associate Professor of Pharmacology & Cancer Biology
Associate Professor of Psychiatry & Behavioral Sciences
Associate Professor in Nursing
Office: 919-681-4775

Laboratory Staff Members

Cory Nanni, Senior Researcher and Lab Manager
Callie Roberts, Research Assistant
Madison Krischak, Research Assistant
Leora Mazumdar, Research Assistant

Chris KeithMolecular Pharmacology Laboratory